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When do two affected people have an unaffected pedigree?
1. If two affected people have an unaffected child, it must be a dominant pedigree: D is the dominant mutant allele and d is the recessive wild type allele. Both parents are Dd and the normal child is dd. 2.
What is the recessive outsider rule in autosomal pedigree?
Recessive outsider rule: outsiders are those whose parents are unknown. In a recessive autosomal pedigree, unaffected outsiders are assumed to be RR, homozygous normal. 5. Children of RR x Rr have a 1/2 chance of being RR and a 1/2 chance of being Rr.
How are pedigrees used to study inherited diseases?
pedigree analysis. 1. Pedigree Analysis A very important tool for studying human inherited diseases These diagrams make it easier to visualize relationships with in families, particularly large extended families. Pedigrees are often used to determine the mode of inheritance (dominant, recessive, etc.) of genetic diseases.
Why do we use Punnett squares in pedigree analysis?
Why do Pedigrees? Punnett squares and chi-square tests work well for organisms that have large numbers of offspring and controlled matings, but humans are quite different: 1.small families. Even large human families have 20 or fewer children. 2. Uncontrolled matings, often with heterozygotes. 3. Failure to truthfully identify parentage. 3
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