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What was the purpose of the triangular ECMO design?
The two-sided triangular design allowed for early stopping for evidence of superiority of ECMO, a predicted lack of a significant difference, or evidence of harm. More details about the design are given in Section II.2 of the Supplementary Appendix.
How long after ECMO does a patient die?
Crossover to ECMO occurred a mean (±SD) of 6.5±9.7 days after randomization in 35 patients (28%) in the control group, with 20 of these patients (57%) dying.
When to use ECMO for hypoxemia patients?
Crossover to ECMO was possible for patients in the control group who had refractory hypoxemia. The primary end point was mortality at 60 days. At 60 days, 44 of 124 patients (35%) in the ECMO group and 57 of 125 (46%) in the control group had died (relative risk, 0.76; 95% confidence interval [CI], 0.55 to 1.04; P=0.09).
How is a prespecified protocol used in ECMO?
A prespecified protocol was used to treat patients in the control group who had undergone randomization at ECMO centers and at non-ECMO centers (see the Supplementary Appendix ). Patients assigned to the ECMO group underwent percutaneous venovenous cannulation.
Last Update: Oct 2021
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